USB is acting cursed on my desktop.

USB Audio Device Properties
Device status:
This device cannot start. (Code 10)
{Operation Failed}
The requested operation was unsuccessful.
an external drive drops out at random, and teh port stays dead until a restart. I updated the chipset driver from ASUS last week, and thats when it started. I checked Device Manager and sometimes a USB cotnroller shows a warning. What should I look at first? Ive already tried another cable and a different device in the same port. Id rather not replace teh motherboard if a setting can fix it.