Long-time player, first time going heavy on mods. about 150 mods in a space exploration RPG, carefully installed, and now it crashes right after the intro:

Fatal error
The game has crashed and will now close.
DXGI_ERROR_DEVICE_REMOVED
The GPU device instance has been suspended.
I read about load order and masters, but I'm overwhelmed :/ Where should I start?
Im using a mod manaegr, not manual installs, so at least I can toggle things easily. I just dont know what to look for in the first place.